##tihuan2##Menin has been best studied as an oncogenic dependency in the context of MLL-rearranged leukemia, in which it binds to the MLL fusion protein and, together with the recruitment of DOT1L, executes the leukemogenic gene expression program . In GIST, both MOZ and Menin–MLL complex members are essential for global chromatin regulation …
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##tihuan2##MLL, the human homolog of Drosophila trithorax, maintains Hox gene expression in mammalian embryos and is rearranged in human leukemias resulting in Hox gene deregulation. How MLL or MLL fusion proteins regulate gene expression remains obscure. We show that MLL regulates target Hox gene expression t …
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##tihuan2##Acute lymphoblastic leukemia (ALL) is a neoplasm of immature lymphoid progenitors that is most commonly of B cell lineage. Most childhood cases of B …
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##tihuan2##Gene rearrangements of the mixed lineage leukemia (MLL) gene cause aggressive leukemia. The fusion of MLL and its partner genes generates various MLL …
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##tihuan2##Chromosomal rearrangements of the mixed lineage leukemia (MLL/KMT2A) gene leading to oncogenic MLL-fusion proteins occur in ~10% of acute leukemias and are associated with poor clinical outcomes ...
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##tihuan2##Huret, JL, Brizard, A, Slater, R, et al. Cytogenetic heterogeneity in t(11;19) acute leukemia: clinical, hematological and cytogenetic analyses of 48 patients -- updated published cases and 16 new ...
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##tihuan2##Blocking the MLL-menin interaction by the expression of a dominant negative inhibitor composed of amino terminal MLL sequences down-regulates Meis1 expression and inhibits cell proliferation, suggesting that targeting this interaction may be an effective therapeutic strategy for leukemias with MLL rearrangements.
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##tihuan2##Menin, which directly binds MLL, has been identified as an essential oncogenic co-factor required for the leukemogenic activity of MLL fusion proteins. Here, we characterize the …
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##tihuan2##1. Cytogenetics and clinical characteristics of MLL associated leukemias. Chromosomal rearrangements at 11q23 are associated with pediatric, adult and therapy-related leukemias and led to the discovery of the Mixed Lineage Leukemia (MLL) gene (1-3). MLL rearrangements fuse the N-terminus of MLL to a fusion partner protein (Figure …
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##tihuan2##Mixed-lineage-leukemia is an aggressive leukemia that predominantly occurs in pediatric patients and is characterized by the expression of fusion genes involving the histone …
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##tihuan2##Abnormalities of the MLL gene were not detected in any of the 15 cases with a deletion or inversion of the chromosomes 11q23 region. The presence of an MLL rearrangement was significantly associated with age less than 1 year (P < .001), leukocyte count –>50 x 10(9)/L (P = .003), and the absence of leukemic cell CD10 expression (P < …
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