##tihuan2##The collected plant samples were allowed to dry at room temperature under the shade; their identification was carried out by a botanist; and the voucher specimens (P1/2021-P12/2021) have been deposited at Mattu University Herbarium. ... The confirmatory qualitative phytochemical screening of plant extracts was performed to …
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##tihuan2##Solid form screening is a crucial step in new drug development because solid forms of a drug substance significantly affect stability, dissolution and manufacturing processes of its drug products. This perspective introduces solid-state science from a practical standpoint, aiming to reduce knowledge gaps and promote communications …
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##tihuan2##The plants were collected from the Toke Kutaye district of the West Shewa Zone and subjected to extraction by using maceration techniques. Phytochemical screening was conducted using various ...
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##tihuan2##In fact, for wet screening to separate rock from clay, the recommended water usage is the highest of any aggregate application: from 5 to 10 gallons per minute per STPH of feed to the screen. In this case, focus the water and water pressure on the top deck and add more spray bars and/or nozzles, to that deck.
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##tihuan2##There are multiple ways to build and design a cleanroom facility that will meet GMP requirements for the sterile manufacturing of drugs. Here is a list of considerations you …
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##tihuan2##Although most screening equipment functions the same, each industry has its own use for these machines. Recycling plants might use screening equipment to separate trash and compost from recyclable materials like glass and plastic. On the other hand, a plant that processes demolition waste will likely use a different type of screening equipment.
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##tihuan2##Generally, class 100 to 100,000 rooms are used in the pharmaceutical industry. [Note – rooms may be classified as clean at class 1 or 10 for other applications, particularly in the microchip /semiconductor industry]. ... Bulk Pharmaceutical Chemical (API) plants handling flammable materials; Oral Solid Dosage (OSD) plants where potent ...
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##tihuan2##These are types of residues for which measurable levels must be determined that are to be safe, acceptable and achievable on equipment surfaces used in the …
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##tihuan2##Quality Control in Pharmaceuticals: Ensuring Product Safety and Efficacy
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##tihuan2##Common types of wet granulation equipment used in the pharmaceutical industry include mixer granulators where the powder is agitated by a large impeller at the base of mixer bowl, or fluid bed granulators where air is blown upwards through the powder to agitate and fluidize the particles.
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##tihuan2##Wet sieving can be used to remove fines of materials that may be difficult to sieve, prior to drying and testing a sample normally. The wet sieving procedure applies to solids with the following properties: Practically …
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##tihuan2##Solid form screening is a crucial step in new drug development because solid forms of a drug substance significantly affect stability, dissolution and manufacturing processes of its drug products.
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##tihuan2##In context of pharmaceutical wet granulation, the end point can be defined as reaching a stage during granulation process, wherein granule properties (e.g., target mean particle size or distribution) and subsequent tableting properties (e.g., tablet hardness, dissolution) are expected to be very similar regardless of wet granulation …
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##tihuan2##antioxidant, antibacterial, and antidandruff activity of leaf extract of A. indica. Materials and Methods: Dried ground leaves were subjected to a cold extraction method using an absolute concentration of methanol, ethanol, and water. Total phenolic, flavonoid, and proanthocyanidin content was estimated by using a linear regression equation from …
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##tihuan2##Fraser Lever was involved in the upgrade and expansion of a US$4.5 million project in Indonesia. The existing crushing plant required expanding to 7Mtpa of product to produce a range of products from 300mm rock …
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##tihuan2##Recently Freeman Technology, a leader in powder characterization techniques, and GEA Pharma Systems, a supplier of pharmaceutical processing solutions, conducted a collaborative experimental study in pursuit of wet granulation process optimization. The work employed GEA's ConsiGma 1 continuous high shear wet …
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##tihuan2##Pharmaceutical quality control testing is usually a matter of repetitive testing of samples of APIs or of a limited number of pharmaceutical products, whereas national quality control laboratories have to be able to deal with a much wider range of pharmaceutical substances and products and, therefore, have to apply a wider variety of test methods.
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##tihuan2##It is the mixture of both the extracted drug material and the solvent of extraction.[2,3] Primary plant constituents. These are mainly nutritional components of plants such as common sugars, amino acid, proteins, and chlorophyll. These have little or no medicinal properties.[6,7] Secondary plant constituents. These are also known as …
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##tihuan2##Wet granulation involves the massing of a mix of dry primary powder particles using a granulating fluid.The fluid contains a solvent which can be removed by drying, and should be non-toxic.Typical solvents …
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##tihuan2##The chief problem of the pharmaceutical formulation of a biological active molecule is to retain its therapeutic activity level at the desired site of action and for the specific time period. Sterilization of pharmaceutical drug substance, as well as excipients, must be required to avoid microbiological contamination (Reineke et al., 2015). For ...
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##tihuan2##The Stack Sizer is a high capacity, multiple deck, wet screening machine capable of high capacity wet screening in a small footprint. A single slurry input is equally divided in a flow divider prior to the Stack Sizer. Each screening deck then makes a particle size separation on the Poly Web Urethane screen surfaces.
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##tihuan2##3. Drug–excipient compatibility studies. These studies are sought after to identify the significant drug–excipient interactions/drug degradation and are based on standard protocols and/existing knowledge on drug degradation pathways [11].The compatibility studies of new chemical entities are invariably designed on the grounds of …
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##tihuan2##Pharmaceutical research and development (R&D) and industry require a continuous fluid-bed dryer that provides a lengthy process time and delivers a high standard for a long time.
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##tihuan2##The pharmaceutical wastes vary greatly depending upon the manufacturing processes. The very nature of the pharmaceutical industry determines the composition of each plant effluent, which varies considerably from plant to plant. There are pharmaceutical plants which discharge only solid wastes, and no waste liquors in the sense of production ...
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##tihuan2##Pharmaceutical Dust characterization and laboratory testing. The pharmaceutical industry sets itself apart from other industries, because of the (costly) nature of the material limits. Thus imposing limits on itself in the milligram quantity of the to be characterized material available, for testing during product development and quality …
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##tihuan2##A cleanroom in the pharmaceutical industry is an extremely sensitive place, due to the regulations set by the FDA on the medical products. Hiring a professional …
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##tihuan2##1. Introduction. With the increasing competition at the global scale and the growing impact of information technology, pharmaceutical industry faces nowadays an urgent need to improve its operational performance and the overall quality of its products [1], [3], [4].Time to market, product quality, regulatory compliance, waste, cost reduction …
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##tihuan2##Small molecules, tablets, capsules, soft gels, effervescence, gummies, and pills. These are all oral solid dosage (OSD) forms, a term that refers to a final drug product therapy that is ingested through the mouth, dissolved in the digestive system, and delivered to the body through absorption into the bloodstream. This widely used and well-proven drug delivery …
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